CMV AND EBV CO-INFECTIONS IN ACTIVE PULMONARY TUBERCULOSIS

Authors

  • Muhammadjonova Dildora Bakhromjon qizi, Rustamova Shohista Amonjonova Author

Keywords:

APT, CMV, EBV

Abstract

Active pulmonary tuberculosis (APT) is a major global health challenge, and viral infections exacerbate the disease. In particular, herpesviruses such as Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) can interact with the immune system and influence the development of TB disease. This review analyzes the relationship between CMV/EBV and TB, based on the available scientific literature, and sheds light on their immunological mechanisms and impact on clinical outcomes.

Author Biography

  • Muhammadjonova Dildora Bakhromjon qizi, Rustamova Shohista Amonjonova

    Namangan State University: 03.00.01 – Intern Researcher in Biochemistry

    Namangan State University: Associate Professor of the Department of Anatomy and Physiology, Doctor of Philosophy (PhD) in Biological Sciences

References

1. Kua, K.P., et al. Cytomegalovirus infection and risk of tuberculosis disease: A systematic

review and meta-analysis. Scientific Reports, 2018, Vol. 8, Article 10355. DOI: 10.1038/s41598-018-

28737-y.

2. Cannon, M.J., Schmid, D.S., Hyde, T.B. Review of cytomegalovirus seroprevalence and

demographic characteristics associated with infection. Reviews in Medical Virology, 2010, 20(4): 202–

213. DOI: 10.1002/rmv.655.

3. Cohen, J.I. Epstein–Barr virus infection. New England Journal of Medicine, 2000, 343(7):

481–492. DOI: 10.1056/NEJM200008173430707.

4. WHO. Global Tuberculosis Report 2023. Geneva: World Health Organization, 2023. ISBN:

978-92-4-007725-2.

5. Redford, P.S., et al. The role of cytomegalovirus and Epstein–Barr virus in tuberculosis

pathogenesis. Frontiers in Immunology, 2014, 5: 448. DOI: 10.3389/fimmu.2014.00448.

6. Griffiths, P., et al. Pathogenesis of human cytomegalovirus in immunocompromised patients.

Journal of Clinical Virology, 2015, 63: 32–37. DOI: 10.1016/j.jcv.2014.12.005.

7. Rickinson, A.B., Kieff, E. Epstein–Barr virus. In: Knipe D.M., Howley P.M. (eds). Fields

Virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2007. pp. 2655–2700.

8. Pai, M., et al. Tuberculosis. Nature Reviews Disease Primers, 2016, 2: 16076. DOI:

10.1038/nrdp.2016.76.

9. Sester, M., et al. Cytomegalovirus infection and T-cell differentiation in healthy donors and

patients with tuberculosis. Journal of Infectious Diseases, 2011, 203(3): 386–394. DOI:

10.1093/infdis/jiq063.

10.Luzuriaga, K., Sullivan, J.L. Infectious mononucleosis and Epstein–Barr virus. New England

Journal of Medicine, 2010, 362(21): 1993–2000. DOI: 10.1056/NEJMra0911116.

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Published

2026-03-29

How to Cite

CMV AND EBV CO-INFECTIONS IN ACTIVE PULMONARY TUBERCULOSIS. (2026). Universal International Scientific Journal, 3(3.1), 825-826. https://universaljournal.uz/index.php/uxij/article/view/324